Etizolam is an effective anti-anxiety medicine that is similar to the benzodiazepine class of medicines and is used for the management of anxiety disorders and short-term treatment of insomnia.
Etizolam Online Australia is a medicine marketed under different brand names, such as Etizest, Etilaam and Atizolm among others and has been marketed since the 1980s.
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It is a thienodiazepine and this compound has a similar chemical structure to benzodiazepines. This substance slows down your central nervous system to relax your muscles.
It was developed in Japan in the 1980s and used for the treatment of anxiety as it can subdue the symptoms of anxiety that occur because of panic disorder and depression. People suffering from Generalized Anxiety Disorder (GAD) can also benefit from this drug.
What disorders is Etizolam used to treat?
Etizolam is used to treat the following disorders:
Generalized anxiety disorder
Generalized anxiety disorder (GAD) is a common type of anxiety disorder that is characterized by chronic worrying, tension, and nervousness. This condition is typically treated with the use of benzodiazepines. However, non-benzodiazepine drugs such as Etizolam have also proven to be effective at reducing the effects of GAD.
Panic disorder is a condition that is characterized by the constant fear of having panic attacks. This condition is usually diagnosed when a patient reports having suffered at least one month of constant worry around having recurring panic attacks. Panic disorder is treated with psychotherapy and/or SSRI drugs such as fluoxetine (Prozac) or sertraline (Zoloft).
A study found that Etizolam reduced chronic anxiety, phobic ideas, and depressive symptoms associated with panic disorder.
Insomnia is a common disorder characterized by sleeping difficulties. Patients suffering from insomnia typically find it hard to fall asleep, stay asleep, and/or wake up too early. Insomnia can be treated with stimulus control therapy, relaxation techniques, and/or medication.
Sedative/hypnotic drugs such as zolpidem (Ambien) and benzodiazepines such as alprazolam (Xanax) are used to help with insomnia. Etizolam has also been found to be effective at helping patients with insomnia.
Thienodiazepines vs benzodiazepines: What’s the difference?
Etizolam is a thienodiazepine which is chemically similar to benzodiazepines. However, the structural formula of thienodiazepines possesses a thiophene ring, while benzodiazepines possess a benzene ring.The sedative effects of Etizolam are weaker than benzodiazepines, but it is also less likely to cause dependence.
Etizolam vs Alprazolam (Xanax)
Both Etizolam and alprazolam (Xanax) are central nervous system depressant drugs used to provide anxiety relief, sedative effects and anticonvulsant effects.
Atizolm is geared towards treating insomnia and anxiety-related disorders. Alprazolam (Xanax) is rarely used to treat sleep disorders as it has a longer duration of action compared to Etizolam and may cause drowsiness the next day.
On the other hand, Etizolam reaches its peak after three hours and then it is slowly flushed out of your system. Therefore, it can help you to sleep peacefully without affecting your performance on the next day.
Etizolam vs Diazepam (Valium)
Valium can be used to decrease anxiety and provide sedative effects similar to Etizolam. However, Etizolam has 10 times the potency of Valium.
Etizolam is used medicinally only in Japan and some parts of Europe, while diazepam and alprazolam are used more widely.
Mechanism of Action
Etizolam is quite like the drug Valium; however, its effects are much more powerful than the widely prescribed drug. People use it to reduce not only anxiety but also convulsions that result from a panic attack. The sedative and hypnotic effects of the drug promote unconsciousness and help to relax muscles.
Though not an ideal way to deal with pain, Etizest can help reduce discomfort and pain for thirty minutes. Low doses of the drug are also effective in relieving the symptoms of vertigo. People dealing with high blood pressure issues can also take it to improve their condition.
Etizolam contains the following:
- Anxiolytic properties that help to manage panic disorder and anxiety.
- Hypnotic properties that help to manage insomnia.
- Anticonvulsant properties that help to control muscle spasm and seizures.
It is a benzodiazepine analog that functions by increasing the action of the chemical messenger “GABA”. Etizolam interacts with GABA receptors to expand their effect and activate them. GABA is one of the biggest inhibitory neurotransmitters in the central nervous system. It works by modulating different physiological processes by slowing the firing of neurons and therefore suppresses the abnormal activity of the nerve’s cells in the brain to produce mood-enhancing and relaxation effects.
Countries like Japan, India, Italy and other European countries have no issues with the potency of the drug and hence, the drug is legally prescribed there. The contradictions that arise about Etizolam are related to its potential as a high abuse drug. People who have a history of prior drug addiction need to be careful when taking Etizest. Since it is an extremely potent drug, the reservations are well-founded.
How to Take Etizolam
Since it is easy to become dependent on Etizolam, the following guide can be used and consult your medical practitioner if further guidance is required. The dosage for Atizolm will vary with the type of disorder it is being used to treat. Etizolam can be taken in the following doses:
- Anxiety disorder: 0.25-0.5mg twice daily
- Panic disorder 0.5mg twice daily
- Insomnia 1-2mg daily.
- Maximum daily dosage: 3mg
Generally, the duration is 6-8 hours with an onset of 30-60 minutes, which peak at 3-4 hours for oral doses. Higher dosage can last longer with after effects lasting between 1-5 hours, however many users have experienced minimal after effects, especially following a 7-8 hour period of uninterrupted sleep.
Though Etizolam is effective in treating a lot of nervous system related issues, it does have some side effects. Overall, it has been reported to be well tolerated with little side effects when prescribed, however some users have reported:
- Decrease in energy
- Decreased heart rate
- Impaired coordination
- Respiratory depression
- Blurred vision
- Constricted pupils
- Decreased appetite
- Nausea and vomiting
- Muscle relaxation
- Dry mouth
- Involuntary eye closure
- Slurred speech
- Rebound insomnia (prolonged use)
At an advanced stage, some people may also experience the following:
- Altered libido
- Severe muscle weakness
- Skin lesions
- Visual impairment
However, it is important to note that these symptoms mostly occur in rare cases. Side effects for women include the ones above and a few more, such as altered menstrual cycle, infertility and breast milk production.
Overdose, Tolerance and Withdrawal Effects
Since Etizolam promotes unconsciousness, always make sure to take the drug supervised. Ask a friend or family member to keep an eye on you after you have taken the drug. This simple precaution can potentially save your life in the event of an overdose.
If you become dependent on Etizest and stop using it suddenly, you can experience withdrawal symptoms that range from mild to severe. The intensity of the effects depends on the duration of the dependency and the user’s prior addiction history. Withdrawal symptoms of Etilaam are tremors, anxiety, excessive sweating, irritability, palpitations, weakness, dizziness and headaches. Some people also reported eating disorders and vomiting as withdrawal effects. These effects will pass by quickly, however, people addicted to high doses can suffer from seizures, hallucinations and mental disorders upon withdrawal. The withdrawal effects can last anywhere from 24 hours to a few days, depending on the dosage and duration of the medicine.
Effects on Women and Children
The effect of Etizolam on pregnant and lactating women is not known. There are possibilities that the drug can transmit through breast milk, but with no research in this area, the doctors are not sure of its effects. That is why pregnant women should always consult their doctor before taking the drug.
Some studies on the drug show that the side effects can be more pronounced for children and they are at a higher risk of negative reactions. However, another study found that only 8% of children in their sample size had adverse reactions to the drug.
Since Etizolam is a sedative itself, taking it with another muscle relaxant or drug of the same consistency can result in enhanced side effects. Experts also advise not to consume alcohol after taking the drug as it can accelerate the drowsiness. Also avoid any CNS-active substances as they can lead to severe medical emergencies, put you in a comatose condition, and potentially cause death.
Users can become dependent on the high potency drug. However, its tendency to cause chemical dependence is lower as compared to benzodiazepines. Symptoms of addiction can appear within 2 weeks. The psychological and mental state of the user is a great determinant in the timeline of dependency. Their prior addiction history and biological makeup are also important factors. This means some people are more susceptible to Etizolam dependency than others. There are some cases of Etizolam dependency in the USA, Japan and India. As for the number of deaths from the drug overdose, there are only 2 reported cases worldwide.
Etizolam can help alleviate the symptoms of extreme anxiety by relaxing muscles and sedation. The high potency drug may be an effective way to treat anxiety related conditions, but it can make users dependent. Keeping this in mind, make sure you do not abuse the drug.
So, if you are starting on Etizolam, make sure to talk to your doctor about your health and other medicines, supplements or herbal products that you are using. If you have any more questions about Etizolam, talk to your doctor, nurse or pharmacist.